
The Angel and the Assassin
The Tiny Brain Cell That Changed the Course of Medicine
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Narrated by:
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Melinda Wade
About this listen
A thrilling story of scientific detective work and medical potential that illuminates the newly understood role of microglia - an elusive type of brain cell that is vitally relevant to our everyday lives.
"The rarest of books: a combination of page-turning discovery and remarkably readable science journalism." (Mark Hyman, MD, number one New York Times best-selling author of Food: What the Heck Should I Eat?)
Named one of the best books of the year by Wired
Until recently, microglia were thought to be helpful but rather boring: housekeeper cells in the brain. But a recent groundbreaking discovery has revealed that they connect our physical and mental health in surprising ways. When triggered - and anything that stirs up the immune system in the body can activate microglia, including chronic stressors, trauma, and viral infections - they can contribute to memory problems, anxiety, depression, and Alzheimer’s. Under the right circumstances, however, microglia can be coaxed back into being angelic healers, able to make brain repairs in ways that help alleviate symptoms and hold the promise to one day prevent disease.
With the compassion born of her own experience, award-winning journalist Donna Jackson Nakazawa illuminates this newly understood science, following practitioners and patients on the front lines of treatments that help to “reboot” microglia. In at least one case, she witnesses a stunning recovery - and in others, significant relief from pressing symptoms, offering new hope to the tens of millions who suffer from mental, cognitive, and physical health issues.
Hailed as a “riveting”, “stunning”, and “visionary”, The Angel and the Assassin offers us a radically reconceived picture of human health and promises to change everything we thought we knew about how to heal ourselves.
©2020 Donna Jackson Nakazawa (P)2020 Random House AudioListeners also enjoyed...
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Don't buy!
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Critic reviews
"A fascinating deep dive into the unsung heroes (and villains) inside our skulls.... Donna Jackson Nakazawa has a journalist’s eye for story, a scholar’s understanding of the research, and a patient’s appreciation for how high the stakes truly are." (Susannah Cahalan, New York Times best-selling author of Brain on Fire)
“In a stunning show of precision and heart, Jackson Nakazawa offers a captivating, page-turning story of scientific discoveries that overturn centuries of medical dogma and fundamentally reshape psychiatry, medicine, and the treatment of mental and physical illnesses. The Angel and the Assassin offers extraordinary promise and heralds hope in a time of skyrocketing rates of ‘microglial’ diseases - including depression, anxiety, Alzheimer’s, and addiction. It is paradigm-shifting reading for us all!” (Christina Bethell, PhD, MPH, director of the Child and Adolescent Health Measurement Initiative and professor at Johns Hopkins University)
“I can think of no topic more fascinating or exciting than microglia, the long-misunderstood brain cells whose power over brain health may hold the promise of cure for so many. The Angel and the Assassin is riveting, engaging, and visionary.” (Terry Wahls, MD, author of The Wahls Protocol)
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Story
There's no such thing as an inevitable midlife crisis, Barbara Bradley Hagerty writes in this provocative, hopeful book. It's a myth, an illusion. New scientific research explodes the fable that midlife is a time when things start to go downhill for everybody. In fact, midlife can be a great new adventure, when you can embrace fresh possibilities, purposes, and pleasures. In Life Reimagined, Hagerty explains that midlife is about renewal.
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For the wealthy
- By A Reader on 02-03-17
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Journey Through Trauma
- A Trail Guide to the 5-Phase Cycle of Healing Repeated Trauma
- By: Gretchen L. Schmelzer PhD
- Narrated by: Adenrele Ojo
- Length: 10 hrs and 21 mins
- Unabridged
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Gretchen Schmelzer watched too many people quit during treatment for trauma recovery. They found it too difficult or too frightening or just decided that for them it was too late. But as a therapist and trauma survivor herself, Dr. Schmelzer wants us to know that it is never too late to heal from trauma, whether it is the suffering caused within an abusive relationship or PTSD resulting from combat.
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Stunningly accurate portrayal of the journey
- By Daniel on 12-11-19
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Come of Age
- The Case for Elderhood in a Time of Trouble
- By: Stephen Jenkinson, Charles Eisenstein - foreword
- Narrated by: Stephen Jenkinson
- Length: 17 hrs and 55 mins
- Unabridged
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Stephen Jenkinson explores the great paradox of elderhood in North America: how we are awash in the aged and yet somehow lacking in wisdom; how we relegate senior citizens to the corner of the house while simultaneously heralding them as sage elders simply by virtue of their age. Our own unreconciled relationship with what it means to be an elder has yielded a culture nearly bereft of them. Taking on the sacred cow of the family, Jenkinson argues that elderhood is a function rather than an identity.
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The Elder I’ve been seeking.
- By dina crosta on 05-18-19
By: Stephen Jenkinson, and others
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Burning Bright
- Rituals, Reiki, and Self-Care to Heal Burnout, Anxiety, and Stress
- By: Kelsey J. Patel
- Narrated by: Kelsey J. Patel
- Length: 12 hrs and 41 mins
- Unabridged
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When Kelsey Patel was struck by searing back pain in her 20s, she had no idea that repressed emotions could manifest as intense anxiety and physical pain. Her healing came from acknowledging the disharmony in her life, which led Patel to seek out the self-care techniques and practices that helped get her body, health, and emotions back into alignment: Reiki, Emotional Freedom Technique, yoga, and other practices.
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READ THIS
- By Julietta Amazon Customer on 05-24-20
By: Kelsey J. Patel
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Die Wise
- A Manifesto for Sanity and Soul
- By: Stephen Jenkinson
- Narrated by: Stephen Jenkinson
- Length: 18 hrs and 43 mins
- Unabridged
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Die Wise does not offer seven steps for coping with death. It does not suggest ways to make dying easier. It pours no honey to make the medicine go down. Instead, with lyrical prose, deep wisdom, and stories from his two decades of working with dying people and their families, Stephen Jenkinson places death at the center of the discussion and asks us to behold it in all its painful beauty. Die Wise teaches the skills of dying, skills that have to be learned in the course of living deeply and well.
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Wonderful book!
- By Kate on 12-22-16
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Aware
- The Science and Practice of Presence - A Complete Guide to the Groundbreaking Wheel of Awareness Meditation Practice
- By: Daniel Siegel M.D.
- Narrated by: Daniel Siegel M.D.
- Length: 15 hrs and 20 mins
- Unabridged
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Aware provides practical instruction for mastering the Wheel of Awareness, a life-changing tool for cultivating more focus, presence, and peace in one's life. An in-depth look at the science that underlies meditation's effectiveness, this audiobook teaches listeners how to harness the power of the principle "Where attention goes, neural firing flows, and neural connection grows". Siegel reveals how developing a Wheel of Awareness practice to focus attention, open awareness, and cultivate kind intention can help you grow a healthier brain and reduce fear and anxiety in your life.
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I've stopped listening after two chapters
- By Mar Sokol on 08-27-18
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Aging Well
- Surprising Guideposts to a Happier Life from the Landmark Study of Adult Development
- By: George E. Vaillant MD
- Narrated by: Keith Sellon-Wright
- Length: 12 hrs and 22 mins
- Unabridged
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Harvard Medical School has followed 824 subjects - men and women, some rich, some poor - from their teens to old age. Harvard's George Vaillant now uses these studies - the most complete ever done anywhere in the world - and the subjects' individual histories to illustrate the factors involved in reaching a happy, healthy old age. He explains precisely why some people turn out to be more resilient than others, the complicated effects of marriage and divorce, negative personality changes, and how to live a more fulfilling, satisfying and rewarding life in the later years.
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Both too detailed and too simple
- By Joseph on 07-14-24
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Exponential Living
- Stop Spending 100% of Your Time on 10% of Who You Are
- By: Sheri Riley, Usher - foreword
- Narrated by: Sheri Riley, full cast
- Length: 13 hrs and 58 mins
- Unabridged
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Constantly striving to achieve one goal after another and investing more in our careers than in our actual lives have left many of us feeling overwhelmed, overworked, and disconnected from who we are. Take Sheri Riley. She rose to the top of her field and was miserable. Sure, she was successful, but she couldn't buy peace, and material possessions didn't bring her clarity. Now an empowerment speaker and life strategist, Sheri Riley shares the secret that helped her regain her sense of self and purpose.
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I did not like this book. At all!
- By Lillie on 02-08-18
By: Sheri Riley, and others
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The Psilocybin Connection
- Psychedelics, the Transformation of Consciousness, and Evolution on the Planet—An Integral Approach
- By: Jahan Khamsehzadeh PhD
- Narrated by: Nathan Agin
- Length: 10 hrs and 12 mins
- Unabridged
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In an ambitious and comprehensive look at psilocybin—and an inside look at how humanity co-evolved alongside "magic" mushrooms—Jahan Khamsehzadeh, PhD, explores our historical and ancestral relationship to psychedelics and presents new and exciting research about what psilocybin can mean for us today.
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Weak on science
- By Shawn on 01-20-23
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Messy
- The Power of Disorder to Transform Our Lives
- By: Tim Harford
- Narrated by: Nicholas Guy Smith
- Length: 9 hrs and 44 mins
- Unabridged
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Messy: The Power of Disorder to Transform Our Lives celebrates the benefits that messiness has in our lives: why it’s important, why we resist it, and why we should embrace it instead. Using research from neuroscience, psychology, social science, as well as captivating examples of real people doing extraordinary things, Tim Harford explains that the human qualities we value – creativity, responsiveness, resilience – are integral to the disorder, confusion, and disarray that produce them.
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I'm a neat freak with three kids...
- By Amazon Customer on 12-13-16
By: Tim Harford
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A Place to Belong
- Celebrating Diversity and Kinship in the Home and Beyond
- By: Amber O'Neal Johnston, Julie Bogart - foreword
- Narrated by: Amber O'Neal Johnston
- Length: 10 hrs and 9 mins
- Unabridged
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Gone are the days when socially conscious parents felt comfortable teaching their children to merely tolerate others. Instead, they are looking for a way to authentically embrace the fullness of their diverse communities. A Place to Belong offers a path forward for families to honor their cultural heritage and champion diversity in the context of daily family life.
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amazing book for homeschool fams
- By Brooke C. on 03-17-25
By: Amber O'Neal Johnston, and others
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Panic Proof
- The New Holistic Solution to End Your Anxiety Forever
- By: Dr. Nicole Cain
- Narrated by: Dr. Nicole Cain
- Length: 12 hrs and 4 mins
- Unabridged
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Panic Proof offers a holistic approach to dealing with panic disorders, amounting to a personalized path to freedom for the millions of people who have had panic attacks. While other books have focused on the thoughts that contribute to panic, Panic Proof is the first book to teach the body that it’s safe in order to prevent panic before it attacks, with remedies ranging from probiotics, herbal remedies, and adaptogens targeted for your anxiety type to healing practices for releasing trauma stored in the body.
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Something here for everyone!
- By Nick Kondyles on 12-25-24
By: Dr. Nicole Cain
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The Orchid and the Dandelion
- Why Some Children Struggle and How All Can Thrive
- By: W. Thomas Boyce MD
- Narrated by: Fred Sanders
- Length: 10 hrs and 23 mins
- Unabridged
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From one of the world's foremost researchers and pioneers of pediatric health - an audiobook that offers hope and a pathway to success for parents, teachers, psychologists, psychiatrists, and child development experts coping with "difficult" children, fully exploring the author's revolutionary discovery about childhood development, parenting, and the key to helping all children find happiness and success.
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Needed an Editor
- By Daniel S Miller on 03-19-19
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Stacked
- Your Super-Serious Guide to Modern Money Management
- By: Joe Saul-Sehy, Emily Guy Birken
- Narrated by: Joe Saul-Sehy, Emily Guy Birken, Julie - Ray Harrison
- Length: 9 hrs and 40 mins
- Unabridged
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Rich. Wealthy. Well-heeled. Moneyed. Affluent. Not bad — but why not get Stacked instead? If you’ve ever dreamed of a basic philosophy of money that’ll help you live bigger, be bolder, and laugh harder, you need this book. In these uncertain times, the basics matter more than ever. But for most of us, concepts such as investing, budgeting, and getting out of debt just don’t float our boats (or 150-foot yachts) — and so we put them off longer than we should.
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Great starter book to conceptualize finance
- By Rick B on 02-15-22
By: Joe Saul-Sehy, and others
Highly recommended!
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Fantastic
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The book provides data that offers so much hope for so many medical issues, especially mental health (the costs of which are 200+billion yearly. I believe I am quoting the author correctly) and a new way to understand why people suffer as they do. There are solutions on the horizon that will advance treatment in ways that will make current treatments seem so limited in outcomes. There is not anyone who will come away without new empathy and understanding of others after reading this book.
THE BEST most life changing book I have ever read!!
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Engaging and hopeful
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Fascinating, Intriguing, Grateful
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An amazingly worthwhile read
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Absolutely fascinating
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Informative and Well Explained
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Unfortunately, the performance of this audiobook was incredibly disappointing. The pronunciation of “microglia” throughout the book is frustrating and very distracting. Of the dozens of microglia researchers I work with, not a single one pronounces it this way. Other key words that are integral to the story of this book such as “tau” are mispronounced as well and make certain chapters hard to follow. That being said, this may not be a huge deal to those outside of the neuro-immune/AD fields. I expect better from Random House Audio, now I’ll think twice before buying science audiobooks from them in the future.
A Magnus Opus for Microglia
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The first chapter is a little dull
There's a few too many people interest stories
The reader mispronounced many things
Pros:
Fantastic science
Short but engaging
Interesting treatment exploration
Medical, but not too complex
Fascinating and interesting
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