The Angel and the Assassin
The Tiny Brain Cell That Changed the Course of Medicine
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Narrated by:
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Melinda Wade
About this listen
A thrilling story of scientific detective work and medical potential that illuminates the newly understood role of microglia - an elusive type of brain cell that is vitally relevant to our everyday lives.
"The rarest of books: a combination of page-turning discovery and remarkably readable science journalism." (Mark Hyman, MD, number one New York Times best-selling author of Food: What the Heck Should I Eat?)
Named one of the best books of the year by Wired
Until recently, microglia were thought to be helpful but rather boring: housekeeper cells in the brain. But a recent groundbreaking discovery has revealed that they connect our physical and mental health in surprising ways. When triggered - and anything that stirs up the immune system in the body can activate microglia, including chronic stressors, trauma, and viral infections - they can contribute to memory problems, anxiety, depression, and Alzheimer’s. Under the right circumstances, however, microglia can be coaxed back into being angelic healers, able to make brain repairs in ways that help alleviate symptoms and hold the promise to one day prevent disease.
With the compassion born of her own experience, award-winning journalist Donna Jackson Nakazawa illuminates this newly understood science, following practitioners and patients on the front lines of treatments that help to “reboot” microglia. In at least one case, she witnesses a stunning recovery - and in others, significant relief from pressing symptoms, offering new hope to the tens of millions who suffer from mental, cognitive, and physical health issues.
Hailed as a “riveting”, “stunning”, and “visionary”, The Angel and the Assassin offers us a radically reconceived picture of human health and promises to change everything we thought we knew about how to heal ourselves.
©2020 Donna Jackson Nakazawa (P)2020 Random House AudioListeners also enjoyed...
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Critic reviews
"A fascinating deep dive into the unsung heroes (and villains) inside our skulls.... Donna Jackson Nakazawa has a journalist’s eye for story, a scholar’s understanding of the research, and a patient’s appreciation for how high the stakes truly are." (Susannah Cahalan, New York Times best-selling author of Brain on Fire)
“In a stunning show of precision and heart, Jackson Nakazawa offers a captivating, page-turning story of scientific discoveries that overturn centuries of medical dogma and fundamentally reshape psychiatry, medicine, and the treatment of mental and physical illnesses. The Angel and the Assassin offers extraordinary promise and heralds hope in a time of skyrocketing rates of ‘microglial’ diseases - including depression, anxiety, Alzheimer’s, and addiction. It is paradigm-shifting reading for us all!” (Christina Bethell, PhD, MPH, director of the Child and Adolescent Health Measurement Initiative and professor at Johns Hopkins University)
“I can think of no topic more fascinating or exciting than microglia, the long-misunderstood brain cells whose power over brain health may hold the promise of cure for so many. The Angel and the Assassin is riveting, engaging, and visionary.” (Terry Wahls, MD, author of The Wahls Protocol)
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Trauma is a fact of life. Veterans and their families deal with the painful aftermath of combat; one in five Americans has been molested; one in four grew up with alcoholics; one in three couples have engaged in physical violence. Dr. Bessel van der Kolk, one of the world’s foremost experts on trauma, has spent more than three decades working with survivors. In The Body Keeps the Score, he uses recent scientific advances to show how trauma literally reshapes both body and brain, compromising sufferers’ capacities for pleasure, engagement, self-control, and trust.
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Overall Worthwhile, Lingers Too Long in the Why
- By LittleBeadsOfMercury on 04-07-21
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A Nation in Pain
- Healing Our Biggest Health Problem
- By: Judy Foreman
- Narrated by: Karen White
- Length: 14 hrs and 57 mins
- Unabridged
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Published in partnership with the International Association for the Study of Pain, A Nation in Pain offers a sweeping, deeply researched account of the chronic pain crisis, from neurobiology to public policy, and presents practical solutions that are within our grasp today. Drawing on both her personal experience with chronic pain and her background as an award-winning health journalist, she guides us through recent scientific discoveries, including genetic susceptibility to pain.
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Broad but superficial.
- By J. P. Murphy on 07-03-15
By: Judy Foreman
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The Last Best Cure
- My Quest to Awaken the Healing Parts of My Brain and Get Back My Body, My Joy, and My Life
- By: Donna Jackson Nakazawa
- Narrated by: Karen Saltus
- Length: 9 hrs and 18 mins
- Unabridged
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Overall
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Performance
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Story
One day Donna Jackson Nakazawa found herself lying on the floor to recover from climbing the stairs. That’s when it hit her. She was managing the symptoms of the autoimmune disorders that had plagued her for a decade, but she had lost her joy. As a science journalist, she was curious to know what mind-body strategies might help her. As a wife and mother she was determined to get her life back. Over the course of one year, Nakazawa researches and tests a variety of therapies including meditation, yoga, and acupuncture to find out what works.
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Amazing book, but struggled with the voice.
- By erin norton on 01-05-18
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Heal Your Mind
- By: Louise Hay
- Narrated by: Mona Lisa Schulz M.D. Ph.D.
- Length: 12 hrs and 28 mins
- Unabridged
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Heal Your Mind continues the three-pronged healing approach that Dr. Mona Lisa Schulz and Louise Hay pioneered together, extending it to conditions, processes, and disorders of the mind including memory, learning disability, addiction, anxiety, and depression. In-depth case studies from the All Is Well Clinic delve into interventions with real patients, where Dr. Mona Lisa uses intuition to pinpoint issues, and she and Louise discuss the medical solutions and affirmations that can help restore well-being.
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Narrator
- By Michylp17 on 11-17-16
By: Louise Hay
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The Emotional Life of Your Brain
- How Its Unique Patterns Affect the Way You Think, Feel, and Live - and How You Can Change Them
- By: Richard J. Davidson Ph.D., Sharon Begley
- Narrated by: Arthur Morey
- Length: 10 hrs and 58 mins
- Unabridged
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Why are some people so quick to recover from a setback while others wallow in despair? Why are some people so highly attuned to others that they seem psychic, while other people put both feet in it over and over again? Why are some people always up and others always down? In this hotly anticipated book, award-winning, pioneering neuroscientist Richard J. Davidson answers these questions by offering an entirely new model of our emotions - their origins, their power, and their malleability.
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Looks Like I Will Be The First Reviewer...
- By Douglas on 11-03-13
By: Richard J. Davidson Ph.D., and others
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A User's Guide to the Brain
- Perception, Attention, and the Four Theaters of the Brain
- By: John J. Ratey
- Narrated by: Eric Martin
- Length: 16 hrs and 38 mins
- Unabridged
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John Ratey, best-selling author and clinical professor of psychiatry at Harvard Medical School, lucidly explains the human brain's workings, and paves the way for a better understanding of how the brain affects who we are. Ratey provides insight into the basic structure and chemistry of the brain, and demonstrates how its systems shape our perceptions, emotions, and behavior. By giving us a greater understanding of how the brain responds to the guidance of its user, he provides us with knowledge that can enable us to improve our lives.
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Great book, mediocre narration
- By Dr. B on 09-25-18
By: John J. Ratey
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Brain Rules for Aging Well
- 10 Principles for Staying Vital, Happy, and Sharp
- By: John Medina
- Narrated by: John Medina
- Length: 8 hrs and 38 mins
- Unabridged
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How come I can never find my keys? Why don't I sleep as well as I used to? Why do my friends keep repeating the same stories? What can I do to keep my brain sharp? Scientists know. Brain Rules for Aging Well, by developmental molecular biologist Dr. John Medina, gives you the facts - and the prescription to age well - in his signature engaging style. With so many discoveries over the years, science is literally changing our minds about the optimal care and feeding of the brain. All of it is captivating. A great deal of it is unexpected.
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Scientific and practical
- By symya08 on 04-29-18
By: John Medina
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How Healing Works
- Get Well and Stay Well Using Your Hidden Power to Heal
- By: Wayne Jonas MD
- Narrated by: Ray Porter
- Length: 11 hrs and 28 mins
- Unabridged
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Drawing on 40 years of research and patient care, Dr. Wayne Jonas explains how 80 percent of healing occurs organically and how to activate the healing process. In How Healing Works, Dr. Wayne Jonas lays out a revolutionary new way to approach injury, illness, and wellness. Dr. Jonas explains the biology of healing and the science behind the discovery that 80 percent of healing can be attributed to the mind-body connection and other naturally occurring processes. Jonas details how the healing process works and what we can do to facilitate our own innate ability to heal.
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AWESOME !
- By Paula on 08-06-18
By: Wayne Jonas MD
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Radical Hope
- 10 Key Healing Factors from Exceptional Survivors of Cancer & Other Diseases
- By: Kelly Turner PhD
- Narrated by: Kelly A. Turner PhD
- Length: 12 hrs and 14 mins
- Unabridged
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Following the publication of the New York Times best-selling Radical Remission, researcher Kelly A. Turner, Ph.D., has collected hundreds of new cases of radical remissions - from cancer and now also other diseases. Turner explores the real-life application of the Radical Remission principles and the people who have chosen to take this journey.
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Everything begins with hope...
- By Rachel Wagner on 08-06-20
By: Kelly Turner PhD
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Transcendence
- Healing and Transformation Through Transcendental Meditation
- By: Norman E. Rosenthal
- Narrated by: Gildart Jackson
- Length: 8 hrs and 4 mins
- Unabridged
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Norman E. Rosenthal, M.D., a 20-year researcher at the National Institute of Mental Health and the celebrated psychiatrist who pioneered the study and treatment of Season Affective Disorder (SAD), brings us the most important work on Transcendental Meditation since the Maharishi Mahesh Yogi's Science of Being and Art of Living - and one of our generation's most significant books on achieving greater physical and mental health and wellness.
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Inspirational yet "Informercional"
- By James on 05-24-13
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The Depression Cure
- The 6-Step Program to Beat Depression without Drugs
- By: Stephen S. Ilardi
- Narrated by: Jeffrey Kafer
- Length: 6 hrs and 49 mins
- Unabridged
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In the past decade, depression rates have skyrocketed, and one in four Americans will suffer from major depression at some point in their lives. Where have we gone wrong? Dr. Stephen S. Ilardi sheds light on our current predicament and reminds us that our bodies were never designed for the sleep-deprived, poorly nourished, frenzied pace of 21st-century life.
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I have a dear family member....
- By Derek B. on 12-12-12
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The Psychopath Inside
- A Neuroscientist's Personal Journey into the Dark Side of the Brain
- By: James Fallon
- Narrated by: Walter Dixon
- Length: 4 hrs and 58 mins
- Unabridged
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The memoir of a neuroscientist whose research led him to a bizarre personal discovery, James Fallon had spent an entire career studying how our brains affect our behavior when his research suddenly turned personal. While studying brain scans of several family members, he discovered that one perfectly matched a pattern he’d found in the brains of serial killers. This meant one of two things: Either his family’s scans had been mixed up with those of felons or someone in his family was a psychopath.
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Entertaining story with some quick neuroscience
- By smarmer on 09-21-14
By: James Fallon
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How to Make Good Things Happen
- Know Your Brain, Enhance Your Life
- By: Marian Rojas Estapé
- Narrated by: Marisol Ramirez
- Length: 7 hrs and 54 mins
- Unabridged
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An empowering journey through the mechanisms of the mind from one of the world’s leading mental health experts.
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it's just ok
- By Serafin Zuniga on 01-18-24
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Anatomy of an Epidemic
- Magic Bullets, Psychiatric Drugs, and the Astonishing Rise of Mental Illness in America
- By: Robert Whitaker
- Narrated by: Ken Kliban
- Length: 13 hrs and 57 mins
- Unabridged
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In this astonishing and startling book, award-winning science and history writer Robert Whitaker investigates a medical mystery: Why has the number of disabled mentally ill in the United States tripled over the past two decades? Every day, 1,100 adults and children are added to the government disability rolls because they have become newly disabled by mental illness, with this epidemic spreading most rapidly among our nations children. What is going on?
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The author does not use a fair scientific approach
- By Michael on 08-15-10
By: Robert Whitaker
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The Secret Life of the Grown-Up Brain
- The Surprising Talents of the Middle-Aged Mind
- By: Barbara Strauch
- Narrated by: Nona Pipes
- Length: 6 hrs and 52 mins
- Unabridged
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A leading science writer examines how the brain's capacity reaches its peak in middle ageFor many years, scientists thought that the human brain simply decayed over time and its dying cells led to memory slips, fuzzy logic, negative thinking, and even depression.
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Recommended for all Ages
- By Virginia A on 05-28-10
By: Barbara Strauch
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Amazing book, but struggled with the voice.
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Childhood Disrupted
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some disturbing content, overall very imformative
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Unwell Women
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Elinor Cleghorn became an unwell woman 10 years ago. She was diagnosed with an autoimmune disease after a long period of being told her symptoms were anything from psychosomatic to a possible pregnancy. As Elinor learned to live with her unpredictable disease, she turned to history for answers, and found an enraging legacy of suffering, mystification, and misdiagnosis. In Unwell Women, Elinor Cleghorn traces the almost unbelievable history of how medicine has failed women by treating their bodies as alien and other, often to perilous effect.
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Profound Read; A Sincere Stepping Stone to Understanding My Own Why
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Probable Impossibilities
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Can space be divided into smaller and smaller units, ad infinitum? Does space extend to larger and larger regions, on and on to infinity? Is consciousness reducible to the material brain and its neurons? What was the origin of life, and can biologists create life from scratch in the lab? Physicist and novelist Alan Lightman explores these questions and more - from the anatomy of a smile to the capriciousness of memory to the specialness of life in the universe to what came before the Big Bang.
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Hooked
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Everyone knows how hard it can be to maintain a healthy diet. But what if some of the decisions we make about what to eat are beyond our control? Is it possible that food is addictive, like drugs or alcohol? And to what extent does the food industry know, or care, about these vulnerabilities? In Hooked, Pulitzer Prize-winning investigative reporter Michael Moss sets out to answer these questions - and to find the true peril in our food.
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Empowering Read
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Water
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Spanning millennia and continents, here is a stunningly revealing history of how the distribution of water has shaped human civilization. Giulio Boccaletti - honorary research associate at the Smith School of Enterprise and the Environment, University of Oxford - shrewdly combines environmental and social history, beginning with the earliest civilizations of sedentary farmers on the banks of the Nile, the Tigris, and the Euphrates Rivers.
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Understand Built-Environment Governance~Know Water
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The Last Best Cure
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One day Donna Jackson Nakazawa found herself lying on the floor to recover from climbing the stairs. That’s when it hit her. She was managing the symptoms of the autoimmune disorders that had plagued her for a decade, but she had lost her joy. As a science journalist, she was curious to know what mind-body strategies might help her. As a wife and mother she was determined to get her life back. Over the course of one year, Nakazawa researches and tests a variety of therapies including meditation, yoga, and acupuncture to find out what works.
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Amazing book, but struggled with the voice.
- By erin norton on 01-05-18
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Childhood Disrupted
- How Your Biography Becomes Your Biology, and How You Can Heal
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The emotional trauma we suffer as children not only shapes our emotional lives as adults but also affects our physical health and overall well-being. Scientists now know on a biochemical level exactly how parents' chronic fights, divorce, death in the family, being bullied or hazed, and growing up with a hypercritical, alcoholic, or mentally ill parent can leave permanent, physical "fingerprints" on our brains.
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some disturbing content, overall very imformative
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Elinor Cleghorn became an unwell woman 10 years ago. She was diagnosed with an autoimmune disease after a long period of being told her symptoms were anything from psychosomatic to a possible pregnancy. As Elinor learned to live with her unpredictable disease, she turned to history for answers, and found an enraging legacy of suffering, mystification, and misdiagnosis. In Unwell Women, Elinor Cleghorn traces the almost unbelievable history of how medicine has failed women by treating their bodies as alien and other, often to perilous effect.
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Can space be divided into smaller and smaller units, ad infinitum? Does space extend to larger and larger regions, on and on to infinity? Is consciousness reducible to the material brain and its neurons? What was the origin of life, and can biologists create life from scratch in the lab? Physicist and novelist Alan Lightman explores these questions and more - from the anatomy of a smile to the capriciousness of memory to the specialness of life in the universe to what came before the Big Bang.
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Mumbler
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Spanning millennia and continents, here is a stunningly revealing history of how the distribution of water has shaped human civilization. Giulio Boccaletti - honorary research associate at the Smith School of Enterprise and the Environment, University of Oxford - shrewdly combines environmental and social history, beginning with the earliest civilizations of sedentary farmers on the banks of the Nile, the Tigris, and the Euphrates Rivers.
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Some Assembly Required
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Over billions of years, ancient fish evolved to walk on land, reptiles transformed into birds that fly, and apelike primates evolved into humans that walk on two legs, talk, and write. For more than a century, paleontologists have traveled the globe to find fossils that show how such changes have happened.
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Interesting but thin. ANNOYING narration
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This America of Ours
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In late-1940s America, few writers commanded attention like Bernard DeVoto. Alongside his brilliant wife and editor, Avis, DeVoto was a firebrand of American liberty, free speech, and perhaps our greatest national treasure: public lands. But when a corrupt band of lawmakers, led by Senator Pat McCarran, sought to quietly cede millions of acres of national parks and other western lands to logging, mining, and private industry, the DeVotos entered the fight of their lives.
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Fascinating history of a great conservationist
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Girls on the Brink
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Anyone caring for girls today knows that our daughters, students, and girls next door are more anxious and more prone to depression and self-harming than ever before. The question that no one has yet been able to credibly answer is Why? Now we have answers. As award-winning writer Donna Jackson Nakazawa deftly explains in Girls on the Brink, new findings reveal that the crisis facing today’s girls is a biologically rooted phenomenon: the earlier onset of puberty mixes badly with the unchecked bloom of social media and cultural misogyny.
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The MOST important book you can read for Girls
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The Deep History of Ourselves
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Renowned neuroscientist Joseph LeDoux digs into the natural history of life on earth to provide a new perspective on the similarities between us and our ancestors in deep time. This pause-resisting survey of the whole of terrestrial evolution sheds new light on how nervous systems evolved in animals, how the brain developed, and what it means to be human. In The Deep History of Ourselves, LeDoux argues that the key to understanding human behavior lies in viewing evolution through the prism of the first living organisms.
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Oversold
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The Adverse Childhood Experiences Guided Journal
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Trauma and its effects can feel like a never-ending storm, and there's no safe harbor in sight from the thoughts and emotions that toss and turn so violently and unpredictably in your head. But healing is possible. Your brain can actually rewire these thoughts and emotions. And you can direct that powerful healing process through journaling.
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An extraordinary healing journal ❤️
- By meredith garner on 08-06-24
By: Donna Jackson Nakazawa, and others
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Smoke and Ashes
- Opium's Hidden Histories
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Overall
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Performance
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When Amitav Ghosh began the research for his monumental cycle of novels the Ibis trilogy ten years ago, he was startled to learn how the lives of the nineteenth-century sailors and soldiers he wrote about were dictated not only by the currents of the Indian Ocean but also by the precious commodity carried in enormous quantities on those currents: opium. Most surprising of all, however, was the discovery that his own identity and family history were swept up in the story. Smoke and Ashes is at once a travelogue, a memoir, and an essay in history, drawing on decades of archival research.
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I adored the narrator
- By J. Dusheck on 06-20-24
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What listeners say about The Angel and the Assassin
Average customer ratingsReviews - Please select the tabs below to change the source of reviews.
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- Janet
- 10-15-23
Highly recommended!
What a genius book, using every day language plus medical language to bring the excitement and thrills to real science. Recommended for everyone. People who know and love anyone who’s had depression or neurologic symptoms may especially enjoy this. This might even change your life for the better while being entertained. Medical people need to be tolerant of the non-standard pronunciation by the narrator. Narrator is very good and the narration lens itself to comfortable listening at a faster playback.
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- Nicole Artz
- 01-20-23
Fantastic
Such a fascinating book! The author weaves together the latest science showing how microglia affect our brains with real life stories of people struggling with mental health issues and the treatments that helped them.
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- Kay
- 08-11-20
THE BEST most life changing book I have ever read!!
The narrator is superb. The writing is superb. The content is of such importance I feel like buying a book for everyone I know and asking them to read it!
The book provides data that offers so much hope for so many medical issues, especially mental health (the costs of which are 200+billion yearly. I believe I am quoting the author correctly) and a new way to understand why people suffer as they do. There are solutions on the horizon that will advance treatment in ways that will make current treatments seem so limited in outcomes. There is not anyone who will come away without new empathy and understanding of others after reading this book.
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- Glenda
- 05-04-21
Engaging and hopeful
I found the information presented in an engaging and thoughtful manner allowing anyone to digest and stay focused as the information and processes were presented. I’ve already downloaded her all of Ms. Nakazawa’s works!
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- K. Fliller
- 07-26-20
Fascinating, Intriguing, Grateful
I am incredibly grateful to Donna Jackson Nakazawa for writing this book. I also read Childhood Disrupted. Both books are beyond stellar. These books read like stories. I can feel her passion for her subject matter. And both books apply to my life. She truly cares about traumatic childhoods and brains that seem to be beyond repair. For people who have suffered greatly and feel like there’s no hope. If I could give these books 1000 stars I would. It truly brought understanding to my complicated world. Thank you so much for your beautiful writing and your dedication to mental health!
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- Donzxsaz
- 02-24-22
An amazingly worthwhile read
A very well written and very interesting read. I’ve learned so much about so much. It is helping me see myself and so many other people that I know in a new light. I can’t recommend it enough. It is totally worth every enjoyable minute.
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- Ollie Incomefree
- 11-03-22
Absolutely fascinating
Thoroughly engrossing book on microglial cells-immunity cells that are neurons. Implications for depression, Dementia, Parkinson’s and more. Solution oriented, with discussions on the latest research and newest techniques.
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- Anna Nelson
- 08-19-20
Informative and Well Explained
This book contains a wealth of information about a new frontier in neuroscience. The case studies really supported the meatier parts of the text.
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- Dominic Acri
- 01-23-20
A Magnus Opus for Microglia
As a neuroscientist, I found this book a refreshing and accurate narrative of the current state of microglial research. Nakazawa brings popular science into the 21st Century of immunology and the brain, exploring cutting-edge research and highlighting some of the most influential scientists in the field. Weaving together narrative and science for the everyday listener, Nakazawa creates a beautiful tapestry befitting of this once understudied cell type.
Unfortunately, the performance of this audiobook was incredibly disappointing. The pronunciation of “microglia” throughout the book is frustrating and very distracting. Of the dozens of microglia researchers I work with, not a single one pronounces it this way. Other key words that are integral to the story of this book such as “tau” are mispronounced as well and make certain chapters hard to follow. That being said, this may not be a huge deal to those outside of the neuro-immune/AD fields. I expect better from Random House Audio, now I’ll think twice before buying science audiobooks from them in the future.
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25 people found this helpful
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Overall
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Performance
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Story
- Kindle Customer
- 03-02-20
Fascinating and interesting
Cons:
The first chapter is a little dull
There's a few too many people interest stories
The reader mispronounced many things
Pros:
Fantastic science
Short but engaging
Interesting treatment exploration
Medical, but not too complex
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